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Alcohol use disorders (AUDs) are characterized by the loss of control over alcohol consumption and the emergence of negative emotionality during abstinence from alcohol. AUDs affect 16 million people in the United States alone and alcohol misuse represents the first risk factor for premature death and disability in young adults worldwide. Current treatment options for AUDs include three FDA-approved medications as well as behavioral therapies, but AUDs have a high rate of relapse even in treated individuals. There is a dire need for more efficient therapeutic strategies and a deep understanding of the neurobiological mechanisms mediating the behavioral symptoms of AUDs is a prerequisite for the rational development of targeted therapies.

While the brain regions and neurotransmitter systems affected by chronic alcohol exposure are well characterized, our understanding of the specific neural circuits and molecular events driving drinking escalation and negative affect during withdrawal remains limited.


The Contet laboratory seeks to fill this gap of knowledge by identifying molecular and circuit mechanisms that causally contribute to the behavioral symptoms of AUDs. To achieve this goal, our projects combine behavioral models of excessive alcohol drinking in mice with genetic engineering methods enabling the manipulation of gene expression and neuronal activity.

The Contet Lab is recruiting

If you have recently graduated (or soon will) and are looking to contribute to our research projects as a postdoc, we want to hear from you!


Winter Conference on Brain Research

Snowbird, UT
Jan 20-25, 2023
Candice will co-chair the panel "New Kid on the Appetite Block: Regulation of Ingestive Behaviors by the Parasubthalamic Nucleus" on Mon 4:30-6:30 pm
Alcoholism and Stress:
A Framework For Future Treatment Strategies

Volterra, Italy
May 16-19, 2023
Jeff will present a talk
"Differential Control of Alcohol Consumption by Neuronal Subpopulations of the Mouse Parasubthalamic Nucleus" 
on Fri 2:00-3:30 pm
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